I would love to hear from you if you are interested in collaboration, writing opportunities, or just for any questions you’d like to ask about my Alzheimer’s research.
I am a research scientist from a multidisciplinary background in physics, applied mathematics, engineering and molecular neuroscience. I have well-developed laboratory and computational modelling skills across these disciplines that are complemented by sound capabilities in qualitative and quantitative analysis. In addition, I am a strong science communicator with expertise in technical and science writing, which has underpinned my ability to work and effectively communicate across different scientific disciplines.
My over-riding research interest is in systems biology, bringing together modelling tools and strengths from my own academic background to help understand the complex mechanisms of Alzheimer’s. I have specific interests in the following factors that I believe may play a role in our genetic susceptibility to developing Alzheimer’s disease.
Hormones: With a disproportionate number of women around the world living with Alzheimer’s, I am interested to explore the unique biological reasons for this difference.
Environmental factors: We are becomingly increasingly exposed to chemicals that are biologically incompatible to our well-being through our food and water supplies, and our physical environment in general. I am interested to understand how this exposure may or may not affect the increasing prevalence of Alzheimer’s in the world today.
- Ten years’ experience in computational modelling including 2D and 3D computational fluid dynamics, and more recently computational systems biology
- Immunohistochemistry, cell culture and analytical techniques
- Experience working effectively within a multidisciplinary team and with the ability to readily adapt to new research areas, technologies and modelling techniques
- Science communication with high level writing, editing, presentation and design skills enabling the understanding of complex technical ideas by a wider audience
- Writing successful and compelling tenders/proposals with net individual values up to AUD $180 million.
- Ph.D in Mechanical Engineering: The University of Sydney, Australia
- M.Sc. in Geophysics: Victoria University of Wellington, NZ
- B.Sc. in Physics and Applied Mathematics: Victoria University of Wellington, NZ
Non-academic
- Diploma in Radio Broadcasting: Radio New Zealand
- Diploma in Freelance Journalism: Australian College of Journalism
A dynamical systems approach for multiscale synthesis of Alzheimer’s pathogenesis. Rollo JL, Crawford J and Hardy J. Neuron.
>> Download a copy at CellPress.
Introducing A New Systems Pathology Paradigm of Alzheimer’s Disease. Rollo JL, Crawford J, Zhang X, Hardy, J. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.
>> Download a copy: http://dx.doi.org/10.1016/j.jalz.2017.06.1927
Unraveling the mechanistic complexity of Alzheimer’s disease through systems biology. Rollo JL et.al. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.
>> Download a copy: http://dx.doi.org/10.1016/j.jalz.2015.10.010.
Up-regulation of matrix metallopeptidase 12 in motor neurons undergoing synaptic stripping. Sajjan S, Holsinger RM, Fok S, Ebrahimkhani S, Rollo J, Banati R, Graeber M. Neurosience.
>> Download a copy: http://dx.doi.org/10.1016/j.neuroscience.2014.05.052
Association Rules Analysis of Comorbidity and Multimorbidity: The Concord Health and Aging in Men Project. Held F, Blyth F, Gnjidic D, Hirani V, Naganathan V, Waite L, Seibel M, Rollo J, Handelsman D, Cumming R, Le Couteur D. The Journals of Gerontology Series A Biological Sciences and Medical Sciences.
>> Download a copy: http://dx.doi.org/10.1093/gerona/glv181
Professor John Crawford, Integrated Solutions Lab Flagship Leader, Rothamsted Research, UK
Professor John Hardy, Professor of Neuroscience, Department of Molecular Neuroscience, Institute of Neurology, UCL, UK
- Honorary Lecturer, Department of Molecular Neuroscience, Institute of Neurology, UCL, UK